Composition
Each tablet contains Albendazole 350mg and Ivermectin 10mg.
Pharmacology
Antiparasitic drugs. Albendazole has broad-spectrum insect repellent activity and has a strong repellent effect on nematodes, tapeworms and trematodes. Its mechanism of action is to combine with the tubulin in the worm to prevent it from multipolymerizing with a-tubulin to form microtubules, thus affecting the cell reproduction process such as mitosis, protein assembly and energy metabolism in the worm.
Ivermectin has a good repellent effect on in vivo and in vitro parasites, especially arthropod insects and in vivo nematodes, and is mainly used to drive away gastrointestinal nematodes, lung nematodes and ectoparasites in cattle, sheep and other animals. Its deworming mechanism is to promote the release of r-aminobutyric acid (GA-BA) from presynaptic neurons, thereby opening GABA-mediated chloride channels. Chloride ion flow can reduce cell membrane impedance, causing slight depolarization of the postsynaptic membrane rest potential, thereby interfering with signal transmission between neuromusculars, making the worm body relax and paralyzed, resulting in the death or excretion of the worm.
Indication
Deworming medicine. It is used to repel or kill nematodes, flukes, tapeworms, mites and other internal and external parasites in cattle and sheep.
Dosage and Administration
Oral administration: One dose, 0.3 tablets per 10kg body weight for cattle and sheep.
Adverse Reactions
According to the prescribed usage and dosage, no adverse reactions have been seen.
Precautions
1. Not to be used during lactation.
2. Ivermectin is highly toxic to shrimp, fish and aquatic organisms. Residues, packages and animal excreta should not pollute the water source.
Withdrawal Period
Cattle, sheep and goats: 35 days
Do not use in lactating animals.
Presentation
3g/bolus × 80bolus/bottle.
Storage
Store in a cool and dry place below 30℃, protect from light.
Keep out of reach of children.
Validity
3 years.