Composition
Each ml contains 17-β estradiol benzoate 5 mg, Vitamin A 12,500 I.U., Vitamin E 5 mg.
Pharmacology
Estradiol can promote the normal growth and development of female organs and parasexual characteristics of female animals. Causes enlargement and secretion of cervical mucosal cells, thickening of the vaginal mucosa, promotes endometrial hyperplasia and increases uterine smooth muscle tone. Estradiol also has an effect on the skeletal system, can increase bone calcium salt deposition, accelerate epiphyseal closure and bone formation, and has the effect of moderately promoting protein synthesis, as well as increasing water and sodium retention. In addition, estradiol negatively regulates the release of gonadotropins from the anterior lobe of the pituitary gland, thereby inhibiting lactation, ovulation, and the secretion of male hormones.
Indications
Sex hormone drugs. It is used for aphrodisiacs of animals with inconspicuous estrus and the discharge of fetal membranes, mummified or dead fetuses.
Dosage and administration
By intramuscular injection.
Horses: 10~20 mg (2~4 ml) per time.
Cattle: 5~20 mg (1~4 ml) per time.
Sheep & goats: 1~3 mg (0.2~0.6 ml) per time.
Dogs: 0.2~0.5 mg (0.04~0.1 ml) per time.
Adverse reactions
(1) In small animals such as dogs, it can cause blood cachexia, which is mostly seen in elderly animals or when applied in large doses. At first, platelets and leukocytosis are increased, but gradually develop into a decrease in platelets and white blood cells. In severe cases it may cause aplastic anemia.
(2) It can cause cystic endometrial hyperplasia and pyometra.
(3) It may prolong the estrus period of cattle and reduce lactation. Precocious puberty and follicular cysts may occur after treatment. The above effects are mostly caused by overdosage, and dose adjustment can reduce or eliminate these adverse reactions.
Precautions and warnings
Do not use in animals in early pregnancy to avoid abortion or fetal deformity.
It can be used for treatment, but should not be detected in animal food.
Withdrawal period
Meat: 28 days.
Milk: 7 days.
Presentation
Available in 10 ml and 20 ml bottles.
Storage
Store in a cool and dry place below 30℃, protect from light.
Validity
3 years.