Composition
Each ml contains:
Procaine benzylpenicillin 120,000 I.U.
Benzathine benzylpenicillin 80,000 I.U.
Dihydrostreptomycin sulphate eq. 200 mg base.
Pharmacological properties
Benzylpenicillin shows a marked bactericidal action against most commonly occurring Gram-positive cocci,bacilli and anaerobes, and also against some Gram-negative germs (e.g. Actinobacillus, Haemophilus, Leptospiren, some Pasteurella strains, anaerobes such as Fusobacterium and Bacteroides). By use of the procaine salt of penicillin G, a high initial penicillin blood level is achieved. The more slowly absorbed benzathine salt provides a prolonged therapeutical blood level for 72 hours.
DHS is an aminoglycoside antibiotic predominantly active against Gram-negative cocci and bacilli, and also against some Gram-positive bacteria (e.g. Staph. aureus, Mycobacterium).
The combination of DHS and penicillin provides a bactericidal synergistic action with a broad spectrum.
Indications
Prevention and treatment of infections caused by penicillin G and/or DHS susceptible microorganisms, such as respiratory tract infections (shipping fever, bronchopneumonias, upper respiratory tract infections), urogenital tract infections (e.g. pyelonephritis by Corynebacterium renale, endometritis), infections of skin and wounds, streptococci infections in horses (strangles, Str. zooepidemicus infections in foals), panaritium, necrobacillosis in calves, anaerobe infections (clostridial infections, tetanus, anthrax), polyarthritis (navel ill), mastitis, septicaemia, bacterial infections secondary to viral ones.
The drug also can be used in postoperative prevention of infections.
Dosage and administration
Shake well before use.
Administer by intramuscular injection.
Cattle: 5 – 10 ml per 100 kg b.w.
Horses, goats, sheep: 5 ml per 50 kg b.w.
Dogs, cats: 0.5 ml per 5 kg b.w.
If necessary, treatment should be repeated after 3 days.
Side effects, contraindications, warnings
Allergic reactions may occur in animals hypersensitive towards penicillins, cephalosporins and
aminoglycosides.
Procaine seldom may cause abortion in sows and nervous reactions in pigs.
Massive doses of dihydrostreptomycin may cause neuromuscular block particularly after accidental I.V. or intraperitoneal injection. Anaesthetics and muscle relaxants potentiate these effects.
Prolonged administration of high doses may lead to deafness, vestibulotoxic (ataxia, incoordination,nystagmus) and nephrotoxic signs.
Contraindications: known hypersensitivity, renal insufficiency.
Withdrawal period
Meat: 30 days.
Milk: 3 days.
Presentation
Available in 100ml glass bottle.
Storage
Store in a cool and dry place below 25℃, protect from light. Keep out of reach of children.
Validity
2 years.