Composition
Each ml contains Tylosin (as Tylosin Tartrate) 300 mg.
Pharmacology
TYLOTONG 30% contains tylosin tartrate as active ingredient. Tylosin is an antibiotic belonging to the group of macrolides; the tartrate salt is very soluble in water. Tylosin interferes with the microbial protein synthesis by inhibiting the enzymatic activity of peptidyltransferase in the ribosomes at the ribosomal 50 S subunit. This causes a bacteriostasis.
Tylosin is a broad-spectrum antibiotic, active against Gram-positive cocci and bacteria (staphylococci, streptococci, Corynebacterium diphteriae), mycoplasmas (Mycoplasma bovis), ureaplasmas.
Tylosin tartrate is absorbed quite quickly from the injection site after intramuscular administration. Tylosin is lipophilic, diffuses very well in the lungs, in the intestinal tissues and in the milk. It is mainly excreted in the bile.
Indications
Tylosin is mainly effective against gram positive organisms, some gram-negative bacteria, spirochaetes, mycoplasma and certain vibrios are also susceptible. It is effective in treatment of calf pneumonia and mycoplasma infections in cattle, sheep and goats. It is also effective in treating infectious sinusitis due to mycoplasma gallisepticum.
Dosage and administration
For intramuscular or subcutaneous injection:
Cattle: 0.3 – 0.6 ml per 10 kg b.w. daily, during 3 – 5 days.
Calves, sheep, goats: 0.2 – 0.25 ml per 10 kg b.w. daily, during 3 – 5 days.
Adverse reactions
Local swelling at the injection site can occur.
Contraindications
Do not administer to horses.
Over dosage
The therapeutic index of tylosin is very large. The risk of overdose is therefore very small. In case of high overdosage convulsic symptoms can be observed. The treatment is symptomatically.
Precautions
Up to maximum of 6 injection, and do not inject more than 5ml at single injection site.
Withdrawal period
Meat: 8 days.
Milk: 4 days.
Presentation
Available in 100ml glass bottle.
Storage
Store in a cool and dry place below 30℃, protect from light. Keep out of reach of children.
Validity
3 years.